Cellular profile of the peritumoral inflammatory infiltrate in squamous cells carcinoma of oral mucosa :correlation with the expression of Ki67 and histologic grading.
September 3rd, 2008 | by admin |Abstract (provisional)BackgroundSquamous cells carcinoma is the most important malignant tumor withprimary site in the oral cavity and, given the great exposure of mucosa and lips to theetiologic factors of this neoplasm, its incidence is high. Investigation of the prognosticdeterminants is significant for the expectations of treatment proposal and cure of thepatient. The local immune response represented by peritumoral inflammatory infiltrateis a possible prognostic factor. Methods: In this study, oral mucosa samples ofsquamous cells carcinoma were analyzed, separated according to their histologicalclassification as well as the phenotypical profile of the cells comprising the peritumoralinflammatory infiltrate was investigated by immunohistochemical method, in addiction,the cell proliferation index via protein Ki67 expression was determinated. Results: TheT lymphocytes made up most of this inflammatory infiltrate, and among these cells,there was a predominance of T CD8 lymphocytes relative to the T CD4 lymphocytes.The B lymhocytes were the second most visualized leucocyte cell type followed bymacrophages and neutrophils. The immunohistochemical assessment of Ki-67 positivecells revealed a greater expression of this protein in samples of undifferentiatedsquamous cells carcinoma. Conclusions: The results suggest that the cellularimmune response is the main defense mechanism in squamous cells carcinoma of oralmucosa, expressed by the large number of T lymphocytes and macrophages, and thatthe greatest intensity of local response may be associated with the best prognosis.
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